Mike Brown has been given a start at full-back, nudging Ben Foden onto the wing. Lancaster has chosen to stick with Brad Barritt and Manu Tuilagi in the centre with Ashton on the opposite wing to Foden. Owen Farrell and Ben Youngs will be England's starting halfback duo for Saturday.
Gloucester-bound Ben Morgan starts at No.8 alongside captain Chris Robshaw and debutant Tom Johnson in the back row. Geoff Parling and Mouritz Botha make-up England's lock partnership with Cole, Hartley and Marler providing the venom of the pack in the front row.
England: Mike Brown, Chris Ashton, Manu Tuilagi, Brad Barritt, Ben Foden, Owen Farrell, Ben Youngs; Joe Marler, Dylan Hartley, Dan Cole, Geoff Parling, Mouritz Botha, Tom Johnson, Chris Robshaw (c), Ben Morgan
Replacements: Lee Mears, Paul Doran Jones, Tom Palmer, Phil Dowson, Lee Dickson, Toby Flood, Jonathan Joseph